![]() ![]() 8 Recommendations were neutral for other drug toxicities. 2A 2016 systematic review supports this approach with a recommendation for lipid emulsion therapy, if other therapies fail, for bupivacaine toxicity (grade 1D) as well as toxicity due to other local anesthetics, amitriptyline, and bupriopion (all grade 2D). Table 1: A selection of lipophilic medications and their partitioning coefficients. See Table 1 for several reference values. 4Īn in-depth review of octanol-water partitioning coefficients is beyond the scope of this article. ![]()
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